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SALOME concluded in late 2015 and results are published in JAMA.

The research concluded that hydromorphone was as effective as diacetylmorphine in treating severe opioid use disorder. In jurisdictions where diacetylmorphine is not available for political and/or regulatory reasons, hydromorphone could be offered as a licensed alternative. Participants on both medications reported far fewer days of street-heroin and other opioid use at six months (three to five days per month), compared to almost daily illicit opioid use prior to being enrolled in the study. Participants also reported a significant reduction in days of illegal activities (from an average of 14.1 days per month to less than four).