The Study to Assess Long-term
Opioid Maintenance Effectiveness
SALOME was a clinical study that tests alternative treatments for people with chronic heroin addiction who are currently not benefiting sufficiently from available treatments such as oral methadone. SALOME compared two similar medications – diacetylmorphine, the active ingredient of heroin, and hydromorphone (HDM), a legal, licensed pain medication. This study also tested if those effectively treated with these two injectable medications could be successfully switched and retained to the oral formulations of the medications. SALOME concluded that hydromorphone was as effective as diacetylmorphine in treating severe opioid use disorder.