Metabolomics in precision medicine (PROOF Centre of Excellence)
In the efforts to develop a system of individualized precision medical options, the integration of metabolomic pathways becomes important. Two methods are commonly used in metabolic profiling.
The first, nuclear magnetic resonance (NMR) spectroscopy, discriminates between metabolites’ proton resonance spectra; the second, mass spectrometry (MS), separates metabolites qualitatively based on molecular and chemical architecture. Analyses account for characteristic alterations in physiological states.
Metabolomic analyses often focus on mechanisms or biomarkers that can better classify one group of individuals from another set of individuals, says Scott Tebbutt Ph.D., CSO at the PROOF (PRevention Of Organ Failure) Centre of Excellence, and associate professor at the University of British Columbia.
Ian Clift reports
Angela White, St. Paul's Hospital Volunteer