Enzyme may be key to stopping fatal sepsis outcomes (Centre for Heart Lung Innovation)
Severe sepsis is an infection from any source that threatens to shut the patient's vital organs down. Four of the top ten causes of death worldwide involve infection and meet the definition of sepsis.
UBC researcher Keith Walley says inhibiting or reducing PCSK9 could allow the patient's body to clear toxic remnants of bacteria and fungi destroyed by antibiotics. Getting rid of the infection's waste may improve the patient's outcomes and survival rates.
The research was conducted by Walley's UBC team, the Centre for Heart Lung Innovation at St. Paul's Hospital and collaborators at the University of Pennsylvania and Chiba University in Japan.
Brian Murphy reports