Dilaudid Subs for Heroin in Supervised Injection Program
Hydromorphone (Dilaudid) may be able to substitute for heroin in medically supervised injection programs, researchers found.
In a single-center randomized study, maintenance hydromorphone didn't meet non-inferiority to maintenance diacetylmorphine (heroin) for days of self-reported street heroin use in the intention-to-treat (ITT) analysis, but it did so in the per-protocol (PP) analysis, according to Eugenia Oviedo-Joekes, PhD, of the University of British Columbia in Vancouver, and colleagues.
It also proved non-inferior in both types of analyses for two other co-primary endpoints, namely self-reported use of any opioid and positive urine screens, they reported online in JAMA Psychiatry.
Kristina Fiore reports