St Paul's Hospital - Providence Health CareGeneral Surgery

Sam M. Wiseman, M.D., F.R.C.S.C., F.A.C.S., Licentiate American Board of Surgery, Michael Smith Scholar

Sam Wiseman

Dr. Wiseman graduated from medical school at the University of Manitoba in Winnipeg and also completed his residency training in General Surgery at the same institution, obtaining his Fellowship in Surgery from the Royal College of Physicians and Surgeons of Canada in 2000.

Dr. Wiseman subsequently moved to Buffalo New York where he spent three years in subspecialty fellowship training at Roswell Park Cancer Institute (RPCI). At RPCI he completed an American Head and Neck Society Advanced Training Council approved Head & Neck Surgery Fellowship, a Society of Surgical Oncology approved Surgical Oncology Fellowship, and an Oncology research fellowship that was focused on studying the molecular biology of cancer. After completing his training Dr. Wiseman joined the staff at St. Paul's Hospital in 2003 and is currently an Associate Professor in the Department of Surgery at the University of British Columbia.

While Dr. Wiseman's surgical practice is concentrated on the treatment of thyroid tumors and parathyroid disease, he still also carries out other cancer surgeries (such as sentinel node biopsy and lymph node dissection), and Endocrine Surgery operations (such as laproscopic cholecystectomy and hernia repair).

While his clinical and basic research are especially focused on thyroid and parathyroid disease, Dr. Wiseman has also continued to study other human cancer types in the laboratory including; breast, colon, rectal, and lung cancers. His research has taken a translational approach, or applied new knowledge/discoveries learned in the laboratory to address important clinical diagnostic, prognostic and treatment questions. Dr. Wiseman has many research collaborators (both clinicians and scientists) and is involved in the training and supervision of many undergraduate, graduate, and postgraduate students.

Dr. Wiseman has published many clinical and scientific research papers and his research has been presented at countless meetings locally, nationally and internationally, and has been recognized with many honors and awards.

Notably, in 2005 Dr. Wiseman was the first surgeon in the history of British Columbia to receive the prestigious Michael Smith Foundation for Health Research Scholar Award.

Also notably, in 2007 Dr, Wiseman was selected from surgeons world-wide to receive the prestigious American College of Surgeons Travelling Fellowship to Japan. Please click here for more information.

And recently Dr. Wiseman was a recipient of a 2008 Canada's Top 40 Under 40 Award. Canada's Top 40 Under 40 is a prestigious national award program that annually honours 40 Canadians in the private, public and not-for-profit sectors under the age of 40. The program, now in its 14th year, is managed by The Caldwell Partners International, a search firm. In addition to The Caldwell Partners, national sponsors include Deloitte, National Bank Financial, The Globe and Mail, and Air Canada. Dr. Wiseman and his peers were selected from over 1100 nominees by an independent Advisory Board, comprised of 25 business leaders from across Canada. Honourees were chosen on five key criteria: vision and leadership; innovation and achievement; impact; community involvement and contribution; and strategy for growth.

Throughout his career Dr. Wiseman has contributed to his profession and society in many different ways (other than clinical, research, and teaching contributions) including serving as a reviewer and editor for many medical journals, acting as a grant reviewer for several granting agencies, member of the Executive Council of the British Columbia Cancer Agency Surgical Oncology Network, Department of Surgery representative for the University of British Columbia Clinical Investigator Program, Endocrine Tumor Group Chair for the British Columbia Cancer Agency, and he is the Director of Research for the Department of Surgery St. Paul's Hospital & Providence Health Care.

Publications

Journals

Wiseman SM: Internal Herniation Through a Defect in the Falciform Ligament: a Case Report and Review of the World Literature. Hernia (2000) 4:117-120.

Wiseman S, Tapia G, Schaaf N, Sullivan, Loree T: Utilization of a Plastic 'Washer' to Prevent Osseointegrated Auricular Prosthesis Abutment Overgrowth: Report of a case and description of a novel technique. The International Journal of Maxillofacial Implants (2001) 16(6):880-882.

*Wiseman S, Loree T, Hicks W, Rigual N: Sentinel Lymph Node Biopsy In Squamous Cell Carcinoma of the Head and Neck: A Major Advance In Staging of the N0 Neck. ENT Journal (2002) 8(3):156-163. Early study showing the limited role of blue dye alone in sentinel node biopsy for head and neck cancer.

*Wiseman S, Popat S, Rigual N, Hicks W, Orner J, Wein R, McGary C, Loree T: Adenoid Cystic Carcinoma of the Paranasal Sinuses or Nasal Cavity: A 40 Year Review of 35 Cases. ENT Journal (2002) 81(8):510-517. Largest experience in the literature reporting the management and outcomes for this rare malignancy.

*Wiseman S, Hicks W, Chu Q, Rigual N: Sentinel Lymph Node Biopsy In Staging Differentiated Thyroid Cancer: A Critical Review. Surgical Oncology (2002) 11(3):1-8. Most comprehensive review in the literature on this controversial topic.

*Wiseman S, Hicks W, Loree T, Al-kasspooles M, Rigual N: Fibrin Glue Assisted Closure Of Post-laryngectomy Pharyngocutaneous Fistula. American Journal Otolaryngology/H&N Surgery(2002) 23(6):368-373. Describes a new technique for managing a dreaded complication of laryngectomy.

**Wiseman S, Loree T, Hicks W, Rigual N, Winston J, Tan D, Anderson G, Stoler D. Anaplastic Thyroid Cancer Evolved From Papillary Carcinoma: Demonstration Of Anaplastic Transformation Utilizing The Inter-simple Sequence Repeat Polymerase Chain Reaction: Archives Of Otolaryngology-Head and Neck Surgery (2003) 129(1):96-100. One of the only publications providing molecular evidence that anaplastic carcinoma arises from differentiated thyroid cancer.

Wiseman S, Rigual N, Alberico R, Sullivan M, Loree T: Ameloblastoma of the Mandible. Journal of the American College of Surgeons (2003) 196(4):654.

Tan D, Li Q, Ramnath N, Wiseman S, Anderson T, Al-Salameh A, Brooks J: Prognostic Relevance Of The Expression Of P53 Oncoprotein In Non-small Cell Lung Cancer. Anticancer Research (2003) 23(2C):1665-1672.

Tan D, Li Q, Deeb G, Slocum H, Ramnath N, Loewen G, Wiseman S, Anderson T, Bepler G Cheney R: Thyroid Transcription Factor-1 (TTF-1) Expression Prevalence and Its Clinical Implications in Non-Small-Cell Lung Cancer: A High Density Tissue Microarray and Immunohistochemistry Study. Human Pathology (2003) 34(6):597-604.

**Wiseman S, Swede H, Stoler D, Anderson G, Rigual N, Hicks W, Douglas W, Tan D, Loree T: Squamous Cell Carcinoma Of The Head And Neck In Nonsmokers And Nondrinkers: An Analysis of Clinicopathologic Characteristics And Treatment Outcomes. Annals of Surgical Oncology (2003) 10(5):551-557. Presents the clinicopathologic characteristics and treatment outcomes of the largest cohort of nonsmoking, nondrinking head and neck cancer patients described in the literature.

*Wiseman S, Loree T, Hicks W, Douglas W, Rigual N, Anderson G, Stoler D: Anaplastic Transformation of Thyroid Cancer: Review of Clinical, Pathological, and Molecular Evidence Provides New Insights Into Disease Biology and Future Therapy. Head And Neck 25 (2003) (8):662-670. Most comprehensive review on a controversial topic.

**Wiseman S, Loree T, Rigual N, Hicks W, Winston J, Swede H, Bartos J, Anderson G, Stoler D: Papillary Thyroid Cancer: High Inter-(Simple Sequence Repeat) Genomic Instability In A Typically Indolent Cancer. Head And Neck (2003) 25(10):825-832. First publication to estimate the number of mutations in the genome of each thyroid cancer cell. The first publication that demonstrates a significant difference in the genomic stability of thyroid cancer in older and younger individuals.

Douglas W, Rigual N, Loree T, Wiseman S, Al-Rawi S, Hicks W: Current Concepts In The Management Of A Second Malignancy Of The Lung In Head And Neck Cancer Patients. Current Opinion In Otolaryngology/Head And Neck Surgery (2003) 11:85-88.

Tan D, Deeb G, Wang J, Slocum H, Winston J, Cheney R, Wiseman S, Beck A, Sait S, Anderson T, Nwogu C: Her-2/neu Protein Expression And Gene Alteration In Stage I-IIIA Non-Small Cell Lung Cancer: A Study of 140 Cases Utilizing A Combination Of High Throughput Tissue Microarray, Immunohistochemistry, and Fluorescent In-situ Hybridization. Diagnostic Molecular Pathology (2003) 12(4):201-211.

*Wiseman S, Stoler D, Anderson G: The Role Of Genomic Instability In The Pathogenesis Of Squamous Cell Carcinoma Of The Head And Neck. Surgical Oncology Clinics Of North America (2004) 13(1):1-11. Presents a thorough review of evidence demonstrating how genomic instability is central to head and neck tumorigenesis.

Rigual N, Wiseman S: Neck Dissection For Head And Neck Squamous Cell Carcinoma: Current Concepts And Future Directions. Surgical Oncology Clinics Of North America (2004) 13(1):151-166.

**Tan D, Wiseman S, Zhou Y, Ward P, Malik D, Rustum Y, J. Brooks: Definition Of A Region Of Loss Of Heterozygosity At Chromosome 11q23.3-25 In Head And Neck Squamous Cell Carcinoma Using Laser Capture Microdissection Technique. Diagnostic Molecular Pathology (2004) 13(1):33-40. Utilizing a novel methodology, this publication is the first to identify a putative tumor suppressor gene on chromosome 11 that may be critical to Head and Neck Tumorigenesis.

Deeb G, Wang J, Ramnath N, Slocum H, Wiseman S, Beck A, Tan D: Altered E-Cadherin and Epidermal Growth Factor Receptor Expressions are Associated with Patient Survival In Non-Small Cell Lung Cancer: A Study Utilizing High-Density Tissue Microarray and Immunohistochemistry. Modern Pathology (2004) 17(4):430-439.

*Wiseman S, Rigual N, Hicks W, Popat S, Lore J, Douglas W, Tan D, Loree T: Parathyroid Carcinoma: A Multicenter Review Of Clinicopathologic Characteristics And Treatment Outcomes. ENT Journal (2004) 83(7):491-494. For the least common endocrine malignancy, this publication reports that 'en bloc' tumor resection should be the preferred surgical approach.

Aljada IS, Ramnath N, Donohue K, Harvey S, Brooks JJ, Wiseman SM, Khoury T, Loewen G, Slocum HK, Anderson TM, Bepler G, Tan D. Upregulation of the Tissue Inhibitor of Metalloproteinase-1 Protein Is Associated With Progression of Human Non-Small-Cell Lung Cancer. Journal Of Clinical Oncology (2004) 22: 3218-3229.

Al-kasspooles MF, Alberico RA, Douglas WG, Litwin AM, Wiseman SM, Rigual NR, Loree TR, Hicks WL: Bronchogenic Cyst Presenting As A Symptomatic Neck Mass In An Adult: Case Report And Review Of The Literature. Laryngoscope (2004) 114:2214-2217.

Wiseman SM, Tomljanovich PI, Rigual NR: Thyroid Lobectomy: Operative Anatomy, Technique, and Morbidity. Operative Techniques In Otolaryngology/Head & Neck Surgery (2004) 13(3) 214-224.

**Hawthorn L, Stein L, Varma R, Wiseman S, Loree T, Tan D: TIMP1 And SERPIN-A Overexpression And TFF3 And CRABP1 Underexpression As Biomarkers For Papillary Thyroid Carcinoma. Head & Neck (2004) 26:1069-1083. First publication to compare gene expression profiles of thyroid cancers, goiters, and normal tissues to identify molecular markers for cancer diagnosis.

Wiseman SM, Tan D, Hill HC: The Double Pylorus: A Report Of 2 Cases And Clinicopathologic Review. Endoscopy (2005) 37:277.

Said M, Wiseman S, Yang J, Al Rawi S, Douglas W, Cheney R, Hicks W, Rigual N, Loree T, Spiegel G, Tan D: Tissue Esinophilia: A Morphologic Marker for Assessing Stromal Invasion in Laryngeal Squamous Neoplasms. BMC Clinical Pathology (2005)5:1-8.

**Wiseman S, Makretsov N, Nielsen T, Gilks CB, Yorida E, Cheang MCU, Turbin D, Gelmon K, Huntsman D: Co-expression of the Type 1 Growth Factor Receptor Family Members HER1, HER2 and HER3 Has a Synergistic Negative Prognostic Effect on Breast Cancer Survival. Cancer (2005) 103(9):1770-1777. First publication to demonstrate the synergistic prognostic significance of coexpression of T1GFR family members by invasive breast cancer.

Baliski C, Stewart J, Anderson D, Wiseman S, Bugis S: Selective Unilateral Parathyroid Exploration: An Effective Treatment of Primary Hyperparathyroidism. American Journal of Surgery (2005) 189:596-600.

*Piper H, Bugis S, Wilkins G, Walker B, Wiseman S, Baliski C: Detecting and Defining Hypothyroidism After Hemithyroidectomy. American Journal of Surgery (2005) 189:587-591. One of few case series and literature reviews of the seldom presented complication of post-hemithyroidectomy hypothyroidism.

Douglas WG, Rigual NR, Geise W, Bauer J, Wiseman SM, Loree TR, Schwarz J, Al-Rawi S, Hicks WL: Advanced Soft Palate Cancer: The Clinical Importance of the Parapharyngeal Space. Otolaryngology Head & Neck Surgery (2005) 133(1):66-69.

Rigual N, Anderson G, Loree T, Wiseman S, Alrawi S, Stoler D. Molecular Prognosticators and Genomic Instability in Papillary Thyroid Cancer. Laryngoscope (2005) 115:1479-1485.

Stoler DL, Bartos JD, Swede H, Edge S, Winston J, Wiseman SM, Anderson G, Stoler D: Genomic Instability In Invasive Breast Carcinoma Measured By Inter-Simple Sequence Repeat PCR. Breast Cancer Research & Treatment (2005) 1:1-4.

Rigual N, Lorre T, Wiseman S, Douglas W, Lamonica D, Cheney R, Hicks W. Sentinel Lymph Node Biopsy: A Rational Approach for Staging T2N0 Oral Cancer. Laryngoscope (2005) 115(12):2217-2220.

*Wiseman SM, Baliski C, Irvine R, Wilkins G, Filipenko D, Zhang H, Bugis S: Hemithyroidectomy Is The Optimal Initial Surgical Approach To Individuals Undergoing Surgery For A Cytologic Diagnosis Of 'Follicular Neoplasm'. Annals of Surgical Oncology (2006) 13(3):1-8. A case series and literature review evaluating a rational surgical approach for management of thyroid nodules diagnosed by needle biopsy as 'follicular neoplasms'.

Messerer CL, Bugis SP, Baliski C, Wiseman SM: Normocalcemic parathyroid carcinoma: an unusual clinical presentation. World Journal of Surgical Oncology (2006) 4(10):1-5.

**Wiseman S, Masoudi H, Niblock P, Turbin D, Rajput A, Hay J, Filipenko D, Huntsman D, Gilks: Derangement Of The E-cadherin/catenin Complex Is Involved In Transformation Of Differentiated To Anaplastic Thyroid Carcinoma. American Journal of Surgery (2006) 191(5):581-587. This publication demonstrates derangement of the cellular adhesion molecules E-cadherin and _-catenin are involved in anaplastic transformation of thyroid cancer.

Melck A, Bugis S, Baliski C, Irvine R, Anderson D, Wilkins G, Zhang H, Wiseman S: Hemithyroidectomy: The Preferred Initial Surgical Approach For Management Of The 'Hurthle Cell Neoplasm'. American Journal of Surgery (2006) 191(5):593-597.

Swede H, Bartos JD, Chen N, Shaukat A, Dutt SS, McQuaid DA, Natarajan N, Rodriguez-Bigas MA, Nowak NJ, Wiseman SM, Alrawi S, Brenner BM, Petrelli NJ, Cummings KM, Stoler DL, Anderson GR: Genomic profiles of colorectal cancers differ based on patient smoking status. Cancer Genetics & Cytogenetics (2006) 15;168(2):98-104.

***Griffith O, Melck A, Jones S, Wiseman SM: A Meta-analysis and Meta-review of Thyroid Cancer Gene Expression Profiling Studies Identifies Important Diagnostic Biomarkers. Journal of Clinical Oncology (2006) 24;31:5043-5051. This publication identifies a core gene expression signature for thyroid cancer through the development of a new methodology for cross platform gene expression study evaluation.

**Wiseman SM, Masoudi H, Niblock P, Turbin D, Rajput A, Hay J, Bugis S, Filipenko D, Huntsman D, Gilks B: Anaplastic Thyroid Carcinoma: Expression Profile Of Targets For Therapy Offers New Insights For Disease Treatment. Annals of Surgical Oncology (2007) 14;2:719-729. Utilizing a TMA based approach this study evaluates many potential novel targets for therapy of anaplastic thyroid cancer.

Stoler D, Nowak N, Matsui S, Wiseman SM, Chen N, Dutt S, Bartos J, Loree TR, Rigual, NR, Hicks WL, Sait S, Anderson GR: Comparative Genomic Instabilities of Thyroid and Colon Cancers. Archives of Otolaryngology/Head & Neck Surgery (2007) 133:457-463.

Wiseman S, Bugis S, MacFarlane J: Jejunal Adenoma Presenting With Gastrointestinal Bleeding. Canadian Journal of Surgery (2007) 50:223-224.

***Wiseman SM, Griffith O, Deen S, Rajput A, Masoudi H, Gilks B, Goldstein L, Gown A, Jones S: Identification of Molecular Markers Altered During Transformation Of Differentiated Into Anaplastic Thyroid Carcinoma. Archives of Surgery (2007) 142:717-727, discussion 727-9. This report is the most comprehensive evaluation of the change in protein expression that occurs during thyroid tumor progression and identifies a marker panel that characterizes transformation.

Kojic LD, Joshi B, Lajoie P, Le PU, Cox M, Turbin DA, Wiseman S, Nabi I:. Raft-dependent Endocytosis of Autocrine Motility Factor Is Phosphatidylinositol-3-Kinase-Dependent In Breast Carcinoma Cells. Journal of Biological Chemistry (2007) 282:29305-29313.

Melck A, Masoudi H, Griffith O, Rajput A, Wilkins G, Bugis S, Jones S, Wiseman S: Evaluation of a Panel of Cell Cycle Regulators in 205 Thyroid Lesions Reveals the Diagnostic and Prognostic Importance of p16, p21, Cyclin D1 and Cyclin E. Annals of Surgical Oncology (2007) 14:3403-3411.

Chooi WK, Brown J, Zetler P, Wiseman S, Cooperberg P: Imaging Of Acute Appendicitis And Its Impact On Negative Appendectomy And Perforation Rates: The St Paul's Experience. Canadian Association of Radiology Journal (2007) 58:220-224.

*Chiu CG, St-Pierre P, Nabi IR, Wiseman SM: Autocrine Motility Factor Receptor: A Clinical Review. Expert Reviews of Anticancer Therapy. Expert Reviews of Anticancer Therapy (2008) 8:207-217. This is the only review that comprehensively evaluates the clinical utility of autocrine motility factor receptor.

**Wiseman SM, Griffith OL, Melck A, Masoudi H, Gown A, MD; Nabi IR, PhD; Jones SJ: Evaluation Of Type 1 Growth Factor Receptor Family Expression In Benign And Malignant Thyroid Lesions. American Journal of Surgery (2008) 195:667-673. This study is the most comprehensive evaluation of thyroid tumors for expression of the type 1 growth factor receptor family.

Leung S, Griffith OL, Masoudi H, Gown A, Jones SJ, Phang PT, Wiseman SM: Clinical Utility Of Type 1 Growth Factor Receptor Expression In Colon Cancer. American Journal of Surgery (2008) 195:604-610.

Maizlin ZV, Wiseman SM, Vora P, Kirby JM, Mason AC, MD, Filipenko D, Brown JA: Hurthle Cell Neoplasms of Thyroid: Sonographic Appearance and Histologic Characteristics. Journal of Ultrasound Medicine (2008) 27:751-7.

Wiseman SM: Report of the 2008 American College of Surgeons Japan Traveling Fellow. Bulletin of the American College of Surgeons (2008) 93(11) 49-53.

*Shoman N, Melck A, Irvine R, Bugis S, Zhang H, Holmes D, Wiseman S: The Utility of Intraoperative Parathyroid Hormone Measurement In Predicting Post-parathyroidectomy Hypocalcemia. Journal Of Otolaryngology (2008) 37:16-22. Reports on novel utility for intraoperative PTH measurement in predicting long term hypocalcemia.

Chiu CG, Harrisson P, Filipenko D, Wiseman SM: Thyroid Invasion By Locally Advanced Esophageal Cancer Masquerading as Anaplastic Carcinoma. Thyroid (2008) 18:799-800.

Kan M, Gill J, Wiseman SM: Colon And Rectal Cancer After Renal Transplantation: A Review. Expert Reviews of Anticancer Therapy (2008) 8:1339-1346.

Goetz J G, Lajoie P, Wiseman SM, Nabi IR: Caveolin-1 In Tumor Progression: The Good, The Bad And The Ugly. Cancer Metastasis Reviews (2008) 27:715-35.

Tee M, Vos P, Zetler P, Wiseman SM: Incidental Littoral Cell Angioma of the Spleen: Case Report. World Journal of Surgical Oncology (2008) 19;6:87-92.

***Wiseman SM, Melck A, Masoudi H, Ghaaidi F, Gown A, Jones S, Griffith O: Molecular Phenotyping of Thyroid Tumors Identifies a Marker Panel for Differentiated Thyroid Cancer Diagnosis. Annals of Surgical Oncology (2008) 15:2811-2826. This report is the most comprehensive protein expression profiling study of thyroid tumors and identifies a molecular marker panel that characterizes benign and malignant thyroid tumors.

*Swanson T, Nanthakumar S, Bugis S, Wiseman S: Extrathyroidal Anaplastic Transformation Case Report & Review. Cancer Therapy (2008) 6:491-494. A case report and review of extra-thyroidal thyroid tumor progression.

**Griffith OL, Chiu CG, Gown AM, Jones SJ, Wiseman SM: Biomarker Panel Diagnosis of Thyroid Cancer: A Critical Review. Expert Reviews of Anticancer Therapy (2008) 8:1399-413. A comprehensive review of biomarker panel diagnosis approaches to thyroid cancer.

Joshi B, Strugnell S, Goetz J, Kojic LD, Cox ME, Wiseman SM, Nabi IR: Phospho-caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration. Cancer Research (2008) 68(20):8210-20.

Kojic LD, Wiseman SM, Ghaidi F, Joshi B, Nedev H, Saragovi HU, Nabi IR: Raft-Dependent Endocytosis of Autocrine Motility Factor/Phosphoglucose Isomerase: A Drug Delivery Route for Tumor Cells. PLoS ONE (2008) 3:e3597. Epub Oct 31.

Wiseman S, Levine D, Sexsmith G, Ling H: Aortopulmonary Window Parathyroid Adenoma. In press, the Journal of the American College of Surgeons.

Lim JP, Irvine R, Bugis S, Holmes D, Wiseman SM: Intact Parathyroid Hormone Level Measured One Hour After Completion or Total Thyroidectomy Predicts Symptomatic Hypocalcemia. In press, American Journal of Surgery.

Deen S, Grifith O, Masoudi H, Gown A, Jones S, Wiseman S: Anaplastic Thyroid Carcinoma Exhibits Intratumoral Molecular Homogeneity for a Therapeutic Target Panel. Anticancer Research (2009) 29(7):2437-44.

Vu L,  Ambrose D, Vos P, Tiwari P, Rosengarten M, Wiseman S: Evaluation of MRI in the Diagnosis of Appendicitis During Pregnancy. Journal of Surgical Research (2009) 156(1):145-149.

Wiseman S, Levine D, Sexsmith G, Ling H: Aortopulmonary Window Parathyroid Adenoma. Journal of the American College of Surgeons (2009) 209(3):412.

Levine DS, Belzberg AS, Wiseman SM: Hybrid SPECT/CT imaging for Primary Hyperparathyroidism: case reports and pictorial review. Clinical Nuclear Medicine (2009) 34(11):779-784.

Johner A, Tiwari P, Zetler P, Wiseman SM: Abdominal Wall Desmoid Tumors Associated With Pregnancy: Current Concepts. Expert Rev Anticancer Therapy (2009) 9(11):1675-1682.

Levine DS, Wiseman SM: Fusion imaging for parathyroid localization in primary hyperparathyroidism. Expert Reviews of Anticancer Therapy (2010) 10(3):353-363.

Chiu CG, Griffith OL, Strugnell SS, Nabi IR, Gown A, Walker B, Wiseman SM: Diagnostic utility of galectin-3 in thyroid cancer. American Journal of Pathology (2010) 176(5):2067-2081.

Swanson T, Chan S, Jones S, Bugis S, Irvine R, Belzberg A, Levine D, Wiseman SM: Determinants of Tc-99m Sestamibi SPECT Scan Sensitivity in Primary Hyperparathyroidism. American Journal of Surgery (2010) 199(5):614-620.

Chiu CG, Masoudi H, Leung S, Voduc DK, Gilks B, Hunstman DG, Wiseman SM: HER-3 Over-Expression is Prognostic of Reduced Breast Cancer Survival:  A Study of 4,046 Patients. Annals of Surgery (2010) 251(6):1107-1116.

Melck AL, Wiseman SM: Harmonic Scalpel versus Conventional Hemostasis in Thyroid Surgery: a Meta-analysis of Randomized Clinical Trials. International Journal of Surgical Oncology 2010 (2010): 1-8.

Kojic S, Strugnell SS, Wiseman SM: Anaplastic Thyroid Cancer: A comprehensive review of novel therapy. Expert Reviews in Anti-Cancer Therapy. (2011) 11(3):387-402.

Yao R, Chui C, Strugnell SS and Wiseman SM: Gender differences in thyroid cancer: a critical review. Expert Reviews of Endocrinology and Metabolism (2011) 6(2):215-243.

Johner A, Griffith OL, Wood L, Piper H, Wilkins G, Walker B, Baliski C, Jones S, Wiseman SM: Detection and Management of Hypothyroidism Following Thyroid Lobectomy: Evaluation of a Clinical Algorithm. Epublished ahead of print in press Annals of Surgical Oncology. (2011) 18(9):2548-2554

Johner A, Faulds J, Wiseman SM: Planned Ilioinguinal Nerve Excision For Prevention Of Chronic Pain After Inguinal Hernia Repair: A Meta-Analysis. Surgery (2011) 150(3):534-541.

Wiseman SM, Gown A, Walker B, Griffith O, Jones S: Immunophenotyping Of Thyroid Tumors Identifies Molecular Markers Altered During Transformation of Differentiated Into Anaplastic Carcinoma. American Journal of Surgery. (2011) 201(5):580-586.

Chiu CG, Yao R, Chan SK, Strugnell SS, Walker B, Jones S, Wiseman SM: Hemithyroidectomy is the Preferred Initial Surgical Approach for Indeterminant Thyroid Lesions. In press Canadian Journal of Surgery.

Wiegand KC, Lee AF, Al-Agha OM, Chow C, Scott D, Steidl C, Wiseman SM. Gascoyne RD, Gilks B, Huntsman DG: Loss of BAF250a (ARID1A) is frequent in high-grade endometrial carcinomas. Journal of  Pathology. (2011) 224(3):328-333.

Halwani Y, Nicolau-Toulouse V, Oakes J, Leipsic J, Geoffrion R, Wiseman SM: Transvaginal Strangulated Small Intestinal Hernia After Abdominal Sacrocolpopexy: Case Report And Literature Review. Hernia. (2011) July 15 Epublished ahead of print.

Wiseman SM, Forrest JI, Chan JE, Zhang W, Hogg RS, Yip B, Lima V, Montaner JSG: Factors Predictive of 30 Day Post-Operative Mortality In HIV/AIDS Patients In The Era Of Highly Active Antiretroviral Therapy. Annals of Surgery. (2012) May 10 Epub ahead of print.

Chiu CG, Chan SK, Fang ZA, Masoudi H, Wood-Baker R, Jones SJM, Laskin J, Wiseman SM: Loss of Beta-catenin Expression is Prognostic of Reduced Survival in Individuals Diagnosed with Resectable Non-small cell Lung Cancer. American Journal of Surgery. (2012) 203(5):654-659.

Kojic K, Kojik S, Wiseman SM: Differentiated Thyroid Cancers: A Comprehensive Review of Novel Targeted Therapies, Expert Reviews of Anticancer Therapy. (2012) 12 (3):345-357.

Shankar J, Wiseman SM, Meng F, Kasaian K, Strugnell S, Mofid A, Jones S, Nabi I: Coordinate Expression of Galectin-3 and Caveolin-1 in Thyroid Cancer. Journal of Pathology. (2012) April 18 Epub ahead of print.

Najafzadeh M, Marra C, Lynd L, Wiseman SM: Cost-effectiveness Of Using Molecular Diagnostic Test To Improve Pre-operative Diagnosis Of Thyroid Cancer. In press Journal of Value in Health.

Johner A, Raymakers A, Wiseman SM: Cost-Utility of Early Versus Delayed Laparoscopic Cholecystectomy for Acute Cholecystitis. Journal of Surgical Endoscopy (2012):27:256-62.

Wiseman S, Walker B: Thyroid Nodules With Indeterminate Cytology. New England Journal of Medicine (2012):367:1957.

Lam E, Strugnell SS, Bajdik CD, Holmes D, Wiseman SM: Limited Adequacy of Thyroid Cancer Patient Follow-Up at a Canadian Tertiary Care Center. In press Canadian Journal of Surgery.

Tee M, Chan S, Nguyen V, Strugnell SS, Yang J, Tiwari, P, Levine D, Jones S, Wiseman SM: Incremental Value and Clinical Impact Of Neck Sonography for Primary Hyperparathyroidism: A Risk-Adjusted Analysis. In press Canadian Journal of Surgery.

Butskiy O, Wiseman SM: Electrothermal Bipolar Vessel Sealing System (LigaSureTM) For Hemostasis During Thyroid Surgery: A Comprehensive Review. In press Expert Reviews Biomedical Devices.

 

Book Reviews

Wiseman S, Kuvshinoff B: Oncologic Emergencies, by PG Johnstone, RAJ Spence. Oncology (2003) 17(5):696.

 

Evidence Based Reviews

Barkun J, Duh Q, Wiseman S: Canadian Association of General Surgeons and American College of Surgeons Evidence Based Reviews in Surgery. 16: Randomized Trial of Parathyroidectomy In Mild Asymptomatic Primary Canadian Journal Of Surgery (2006) 49(1):59-61.

 

Book Chapters

Griffith O, Melck A, Jones S, Wiseman S (2007): Thyroid Cancer: Identification of Gene Expression Markers for Diagnosis, in Methods of Cancer Diagnosis, Therapy, and Prognosis, M.A. Hayatt Editor, 1st edition.

Galindo S, Wiseman SM (2013): Anaplastic Thyroid Cancer: Current Concepts Head and Neck Clinics Volume 7: Management of Thyroid Cancer: Special Considerations (in press).